13c-metabolic-flux
Estimates intracellular metabolic fluxes from steady-state carbon-13 isotope-tracing measurements using validated atom maps,โฆ
Builds, evaluates, and audits right-censored or competing-risk survival workflows with scikit-survival, including leakage-safe preprocessing, model selection, probability prediction, and censoring-aware metrics.
Claude Code
$ npx -y skills add K-Dense-AI/scientific-agent-skills --skill scikit-survival --agent claude-code
Codex
$ npx skills add K-Dense-AI/scientific-agent-skills --skill scikit-survival -a codex -y
Cursor
$ npx skills add K-Dense-AI/scientific-agent-skills --skill scikit-survival -a cursor -y
Gemini CLI
$ npx skills add K-Dense-AI/scientific-agent-skills --skill scikit-survival -a gemini-cli -y
GitHub Copilot
$ npx skills add K-Dense-AI/scientific-agent-skills --skill scikit-survival -a github-copilot -y
OpenCode
$ npx skills add K-Dense-AI/scientific-agent-skills --skill scikit-survival -a opencode -y
Windsurf
$ npx skills add K-Dense-AI/scientific-agent-skills --skill scikit-survival -a windsurf -y
name: scikit-survival description: Builds, evaluates, and audits right-censored or competing-risk survival workflows with scikit-survival, including leakage-safe preprocessing, model selection, probability prediction, and censoring-aware metrics. license: MIT compatibility: Requires Python 3.11+, uv, and the pinned scikit-survival 0.28.0 stack for executable examples. Bundled CLIs are local and network-free by default. allowed-tools: Read Write Edit Bash metadata: version: "1.4" last-reviewed: "2026-10-01" skill-author: K-Dense Inc.
Use this skill for scikit-survival 0.28.0 workflows involving:
scikit-survival primarily models right-censored outcomes. Its built-in competing-risk support is nonparametric cumulative incidence; it does not provide Fine-Gray regression. Do not present model output as clinical advice, causal evidence, or proof of clinical utility.
Python snippets using study-defined variables such as `X_train`, `y_train`, `frame`, or `times` are illustrative integration templates. The native regression tests and local CLI smoke runs use small synthetic fixtures; they do not validate an unprovided study, clinical dataset, or every optional dataframe backend.
Verified 2026-10-01:
x86-64, macOS x86-64/ARM64, and Windows x86-64.
scikit-learn >=1.9.0,<1.10, OSQP >=1.0.2, narwhals >=2.0.1.
`criterion` from `GradientBoostingSurvivalAnalysis`.
The native refresh tests used Python 3.13 and the following snapshot (NumPy 2.5.1 was cached; this is a tested snapshot, not a claim that every pin is newest). Create an isolated environment:
uv venv .venv-survival --python 3.13 source .venv-survival/bin/activate uv pip install \ "scikit-survival==0.28.0" \ "scikit-learn==1.9.1" \ "numpy==2.5.1" \ "pandas==3.0.6" \ "scipy==1.18.1" \ "ecos==2.0.14" \ "osqp==1.1.3" \ "joblib==1.6.0" \ "numexpr==2.14.2" \ "narwhals==2.26.0"
Binary wheels are preferred. A source build requires a C/C++ compiler; OSQP may also require CMake. This skill is MIT-licensed; the upstream scikit-survival package is GPL-3.0-or-later, so review upstream licensing before redistribution.
1. **Define the estimand and event coding.** Decide whether the target is all-event survival, cause-specific hazard, or cause-specific cumulative incidence. 2. **Validate outcomes.** Standard estimators need a two-field structured array: boolean event first, observed time second. Competing-risk CIF instead needs a separate integer event vector: 0=censored, 1..K=causes. 3. **Split before learned preprocessing.** Never fit imputers, encoders, scalers, feature selectors, or alpha choices on all rows before splitting. 4. **Fit preprocessing inside a pipeline.** Unknown categories and missingness must be handled using training-fold state only. 5. **Tune without reusing evaluation data.** Use nested CV when reporting cross-validated tuned performance, or reserve a truly untouched final holdout. 6. **Fit censoring distributions on training data.** IPCW concordance, dynamic AUC, and Brier metrics receive `survival_train`, never a pooled train+test outcome. 7. **Restrict evaluation times.** Use a strictly increasing grid inside test follow-up and below the end of training support where the estimated censoring survival remains positive. 8. **Match predictions to metrics.** Concordance/dynamic AUC consume higher-is-riskier scores. Brier metrics consume survival probabilities with shape `(n_test, n_times)`, not risk scores or unevaluated step functions. 9. **Handle competing causes explicitly.** Standard survival probabilities and CIFs answer different questions. Never estimate event-specific probability with `1 - Kaplan-Meier` while censoring competing events. 10. **Report limits.** Separate discrimination, calibration, prediction error, and cumulative incidence. None alone establishes decision or clinical utility.
from sksurv.util import Surv
y = Surv.from_arrays(event=event_bool, time=observed_time)
# Equivalent for pandas or Polars:
y = Surv.from_dataframe("event", "time", frame)The first field is boolean (`True`=event, `False`=right-censored); the second is floating-point time. Field names may vary, but field order and meaning may not. Use `references/data-handling.md` before loading custom or competing-risk data.
from sklearn.compose import ColumnTransformer
from sklearn.impute import SimpleImputer
from sklearn.model_selection import train_test_split
from sklearn.pipeline import make_pipeline
from sklearn.preprocessing import OneHotEncoder, StandardScaler
from sksurv.linear_model import CoxPHSurvivalAnalysis
X_train, X_test, y_train, y_test = train_test_split(
X, y, test_size=0.25, stratify=y["event"], random_state=20260723
)
preprocess = ColumnTransformer(
[
("num", make_pipeline(SimpleImputer(strategy="median"), StandardScaler()), numeric),
(
"cat",
make_pipeline(
SimpleImputer(strategy="most_frequent"),
OneHotEncoder(handle_unknown="ignore", drop="first", sparse_output=False),
),
categorical,
),
],
sparse_threshold=0.0,
)
model = make_pipeline(p๐ Claude Scientific Skills is now Scientific Agent Skills. Same skills, broader compatibility โ now works with any AI agent that supports the open Agent Skills standard, not just Claude.
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