/nutrigx

name: nutrigx
description: Personalised nutrition report from consumer genetic data (23andMe, AncestryDNA, VCF) — interrogates nutritionally-relevant
  SNPs and generates actionable dietary guidance, all computed locally.
license: MIT
metadata:
  version: 0.2.0
  author: David de Lorenzo
  tags:
  - nutrigenomics
  - nutrition
  - diet
  - genetics
  - 23andme
  - ancestrydna
  - vcf
  openclaw:
    requires:
      bins:
      - python3
    always: false
    emoji: 🥦
    homepage: https://github.com/ClawBio/ClawBio
    os:
    - darwin
    - linux
    install:
    - kind: pip
      package: pandas numpy matplotlib seaborn
    - kind: pip
      package: reportlab
    trigger_keywords:
    - personalised nutrition
    - nutrigenomics
    - diet genetics
    - MTHFR
    - APOE
    - FTO
    - vitamin D
    - caffeine metabolism
    - lactose
    - omega-3
    - folate
    - what should I eat based on my DNA
    - vitamin absorption genetics
    - gluten

NutriGx Advisor — Personalised Nutrition from Genetic Data

**Author**: David de Lorenzo (ClawBio Community) **Requires**: Python 3.11+, pandas, numpy, matplotlib, seaborn, reportlab (optional)

---

What This Skill Does

The NutriGx Advisor generates a **personalised nutrition report** from consumer genetic data (23andMe, AncestryDNA raw files or VCF). It interrogates a curated set of nutritionally-relevant SNPs drawn from GWAS Catalog, ClinVar, and peer-reviewed nutrigenomics literature, then translates genotype calls into actionable dietary and supplementation guidance — all computed locally.

**Key outputs**

• Markdown nutrition report with risk scores and recommendations
• Radar chart of nutrient risk profile
• Gene × nutrient heatmap
• Reproducibility bundle (`commands.sh`, `environment.yml`, SHA-256 checksums)

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Trigger Phrases

The Bio Orchestrator should route to this skill when the user says anything like:

• "personalised nutrition", "nutrigenomics", "diet genetics"
• "what should I eat based on my DNA"
• "nutrient metabolism", "vitamin absorption genetics"
• "MTHFR", "APOE", "FTO", "BCMO1", "VDR", "FADS1/2"
• "folate", "omega-3", "vitamin D", "caffeine metabolism", "lactose", "gluten"
• Input files: `.txt` or `.csv` (23andMe), `.csv` (AncestryDNA), `.vcf`

---

Curated SNP Panel

Macronutrient Metabolism

| Gene | SNP | Nutrient Impact | Evidence | |---------|------------|------------------------------------------|----------| | FTO | rs9939609 | Energy balance, fat mass, carb sensitivity | Strong (GWAS) | | PPARG | rs1801282 | Fat metabolism, insulin sensitivity | Moderate | | APOA5 | rs662799 | Triglyceride response to dietary fat | Strong | | TCF7L2 | rs7903146 | Carbohydrate metabolism, T2D risk | Strong | | ADRB2 | rs1042713 | Fat oxidation, exercise × diet interaction | Moderate |

Micronutrient Metabolism

| Gene | SNP | Nutrient | Effect of risk allele | |---------|------------|-------------------------|----------------------------------| | MTHFR | rs1801133 | Folate / B12 | ↓ 5-MTHF conversion (~70%) | | MTHFR | rs1801131 | Folate / B12 | ↓ enzyme activity (~30%) | | MTR | rs1805087 | B12 / homocysteine | ↑ homocysteine risk | | BCMO1 | rs7501331 | Beta-carotene → Vitamin A | ↓ conversion (~50%) | | BCMO1 | rs12934922 | Beta-carotene → Vitamin A | ↓ conversion (compound het) | | VDR | rs2228570 | Vitamin D absorption | ↓ VDR function | | VDR | rs731236 | Vitamin D | ↓ bone mineral density response | | GC | rs4588 | Vitamin D binding | ↑ deficiency risk | | SLC23A1 | rs33972313 | Vitamin C transport | ↓ renal reabsorption | | ALPL | rs1256335 | Vitamin B6 | ↓ alkaline phosphatase activity |

Omega-3 / Fatty Acid Metabolism

| Gene | SNP | Nutrient | Effect | |---------|------------|----------------------|---------------------------------| | FADS1 | rs174546 | LC-PUFA synthesis | ↑/↓ EPA/DHA from ALA | | FADS2 | rs1535 | LC-PUFA synthesis | Modulates omega-6:omega-3 ratio | | ELOVL2 | rs953413 | DHA synthesis | A allele: lower EPA→DHA conversion (association, not a requirement) | | APOE | rs429358 | Saturated fat response | ε4 → ↑ LDL-C on high SFA diet | | APOE | rs7412 | Saturated fat response | Combined with rs429358 for ε typing |

Caffeine & Alcohol

| Gene | SNP | Compound | Effect | |---------|------------|-------------|--------------------------------| | CYP1A2 | rs762551 | Caffeine | Slow/Fast metaboliser | | AHR | rs4410790 | Caffeine | Modulates CYP1A2 induction | | ADH1B | rs1229984 | Alcohol | Acetaldehyde accumulation risk | | ALDH2 | rs671 | Alcohol | Asian flush / toxicity risk |

Food Sensitivities

| Gene | SNP | Sensitivity | Effect | |---------|------------|----------------------|---------------------------------| | MCM6 | rs4988235 | Lactose intolerance | Risk allele G (GRCh38 plus / -13910C) is non-persistence; persistence allele A (-13910T) is dominant | | HLA-DQ2 | Proxy SNPs | Coeliac / gluten | HLA-DQA1/DQB1 risk haplotypes |

Antioxidant & Detoxification

| Gene | SNP | Pathway | Effect | |---------|------------|----------------------|---------------------------------| | SOD2 | rs4880 | Manganese SOD | ↓ mitochondrial antioxidant | | GPX1 | rs1050450 | Selenium / GSH-Px | ↓ glutathione peroxidase | | GSTT1 | Deletion | Glutathione-S-trans | Null genotype → ↑ oxidative risk| | NQO1 | rs1800566 | Coenzyme Q10 | ↓ CoQ10 regenerati